Not taking a high priced listing

Recently, I have come across situations where the would be Sellers are upside down or they will have to bring money to the table as they have no hardship and are selling because of better opportunities or changes in their life situations. Hence, there cannot be forgiveness (if they think there will be from Banks/Lenders & I say otherwise).
I have given a price at which their house will be in the market versus just taking the listing to put it in the MLS , a price they did not want to hear and therefore, the listing has been taken by another agent.
Of course, It's not gone under agreement. But tell me, Should I have taken the listing or am I better off without that listing...

Mortgage & Implications on Housing

Although the rates are low, I have come across situations where 100% financing is almost non existent, jumbo loans are difficult to get & if you are qualified, the rates on the second loan is almost 7.5 % - 8 %.
With this situation, would it be fair to say that the drop that we have seen in prices of houses in Massachusetts, will be somewhat offset by the monthly mortgage payments.
Any thoughts!!